Target Identification and Validation

Identify parasite metabolic pathways, proteins or metabolites that can be targeted by candidate drugs

SOURCES AND APPROACHES Bioinformatics Mining of public domain information to collect, curate, annotate and archive information on druggable or potentially druggable targets in Plasmodium species. Biochemistry Establishment and validation of microplate assays of target binding and functional inhibition.  Target validation          Demonstration of parasite inhibition in culture or in vivo upon target-          candidate interaction. Genetic and/or chemical validation of target.