Ranking among infectious diseases with the most severe human costs, malaria poses an immense challenge to those engaged in the search for new drugs against the disease. Malaria is caused by species of the protist Plasmodium with P. falciparum and P. vivax being responsible for most infections. The disease is endemic in several regions of the world including sub-Saharan Africa and South Asia. The growing resistance of the malaria parasite to currently used anti-malarial drugs coupled with its complex life cycle necessitates the search for new drugs through efforts that bring together diverse capabilities across the world.